Abstract: This paper discusses the issue of multiple targets Direction Of Arrival (DOA) estimation for Spatially Spread Polarization Sensitive Array (SS-PSA). First, the signal model of sparsely uniform SS-PSA with three orthogonally oriented polarized-antenna is presented. Then the rotational invariance of the proposed uniform array is utilized to calculate the ambiguous DOA estimation by means of ESPRIT method. The spatial phase shift raised by spatially spread polarized-antenna is compensated by the ambiguous DOA estimation to obtain virtual collocated polarized-antenna. The corresponding virtual DOA estimation is calculated by the multi-dimensional angle structure among the virtual collocated polarized-antenna. Finally, the multiple targets DOA estimation is obtained by extracting the minimum norm of the difference between the ambiguous DOA estimation and the corresponding virtual DOA estimation. The proposed array can reduce the array mutual coupling by using the spatially spread polarized-antenna instead of conventional collocated polarized-antenna. Moreover, the DOA estimation accuracy can be improved greatly because of the extended aperture offered by the sparse array. Computer simulation results verify the effectiveness and high-accuracy of the proposed SS-PSA DOA estimation algorithm.