Abstract: The design of shift sequences is the key issue of the Zero Correlation Zone (ZCZ) construction based on interleaving technique. The restriction condition is analyzed according to the correlation function and accordingly a method of ZCZ sequence set construction based on interleaving is derived. Sequence pairs with flexible ZCZ are brought out by using diverse base sequence and shift sequences which satisfy the restrict condition. ZCZ sequence pairs set with certain length and volume is constructed by uniting the new ZCZ sequence pair and orthogonal matrix. This method extends the utilization of interleaving technique which can generate sequence pairs set with some volume and flexible ZCZ.