DNA数据存储

毛秀海; 李凡; 左小磊

doi:10.11999/JEIT190852

DNA数据存储

doi: 10.11999/JEIT190852

1.
上海交通大学医学院分子医学研究院上海 200127
2.
上海交通大学医学院附属仁济医院上海 200127

基金项目: 中国科学技术部国家重点研发计划(2018YFA0902600)，国家自然科学基金(21804019, 21804088)，上海市浦江人才计划(19PJ1407300)

详细信息

作者简介:
毛秀海：男，1986年生，副研究员，研究方向为DNA纳米技术

李凡：男，1983年生，副研究员，研究方向为分子医学及DNA纳米技术

左小磊：男，1980年生，研究员，研究方向为DAN电化学传感器、3D DNA探针和癌症早期诊断

通讯作者:
左小磊　zuoxiaolei@sjtu.edu.cn

中图分类号: TP391
计量
- 文章访问数: 4027
- HTML全文浏览量: 1230
- PDF下载量: 234
- 被引次数: 0
出版历程
- 收稿日期: 2019-11-01
- 修回日期: 2020-05-18
- 网络出版日期: 2020-05-21
- 刊出日期: 2020-06-22

DNA Data Storage

1.
Institute of Molecular Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
2.
Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

Funds: The Ministry of Science and Technology of China (2018YFA0902600), The National Natural Science Foundation of China (21804019, 21804088), Shanghai Pujiang Program (19PJ1407300)

摘要

摘要: 分子数据存储作为一种稳定性强、存储密度高的数据存储方式，表现出巨大的潜力。它有望解决当今日益增长的巨大信息量与存储能力之间差距不断扩大的问题。作为一种典型的分子数据存储方式，DNA数据存储可以作为一种替代性、变革性的存储介质，用于突破现用存储方式的物理极限，满足不断增加的数据存储需求。该综述将对DNA数据存储的历史、工作流程、及当前的发展状态进行概述，同时讨论现今DNA数据存储存在的问题、挑战及发展趋势。
- 分子数据存储 /
- DNA数据存储 /
- 编码 /
- 解码 /
- 读取
Abstract: Molecular data storage has great potential as durable and high-density data-storage media, which will deal with the growing gap between produced information and the data storage ability. With storing data in molecular form, DNA can provide alternative substrates for storage to overcome the physical limits for existing medias. This review provides an overview of the history, process and the current status of the DNA data storage, and presents the problems of current data storage technology.
- Molecular data storage /
- DNA data storage /
- Encoding /
- Decoding /
- Read

HTML全文

图 1 DNA数据存储整体框架图

下载: 全尺寸图片幻灯片

表 1 体外DNA数据存储比较研究

文献	数据容量	合成方法	测序方法	物理冗余 (覆盖率)	重新组装	链长 (碱基数)	逻辑密度 (bit/碱基)	逻辑密度 (有效载荷)	是否能随机访问
文献[31]	650 kB	亚磷酰胺(沉积)	合成测序	3000×	索引序列连接	115	0.60	0.83	否
文献[32]	630 kB	亚磷酰胺(沉积)	合成测序	51×	重叠序列连接	117	0.19	0.29	否
文献[17]	80 kB	亚磷酰胺(电化学)	合成测序	372×	索引序列连接	158	0.86	1.16	否
文献[37,45]	3 kB	亚磷酰胺(沉积)	纳米孔测序	200×	索引序列连接	880～1000	1.71	1.74	是
文献[38]	2 MB	亚磷酰胺(沉积)	合成测序	10.5×	种子序列连接	152	1.18	1.55	否
文献[46]	22 MB	亚磷酰胺(沉积)	合成测序	160×	索引序列连接	230	0.89	1.08	否
文献[36]	150 kB	亚磷酰胺(电化学)	合成测序	40×	索引序列连接	117	0.57	0.85	是
文献[12]	200 MB	亚磷酰胺(沉积)	合成测序	5×	索引序列连接	150～200	0.81	1.10	是
文献[43]	8.5 MB	亚磷酰胺(沉积)	合成测序	164×	索引序列连接	194	1.94	2.64	否
文献[44]	854 kB	亚磷酰胺(柱子)	合成测序	250×	索引序列连接	85	1.78	3.37	否
文献[12]	33 kB	亚磷酰胺(沉积)	纳米孔测序	36×	索引序列连接	150	0.81	1.10	是
文献[47]	18 B	酶(柱基)	纳米孔测序	175×	无(单体)	150～200	1.57	1.57	否

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