基于DNA折纸基底的与非门计算模型

殷志祥; 唐震; 张强; 崔建中; 杨静; 王日晟; 赵寿为; 张居丽

doi:10.11999/JEIT190825

基于DNA折纸基底的与非门计算模型

doi: 10.11999/JEIT190825

殷志祥^{1, 2},
唐震^2, ,,
张强³,
崔建中⁴,
杨静²,
王日晟²,
赵寿为¹,
张居丽¹

1.
上海工程技术大学数理与统计学院上海 201620
2.
安徽理工大学数学与大数据学院淮南 232001
3.
大连理工大学计算机科学与技术学院大连 116024
4.
淮南联合大学计算机系淮南 232001

基金项目: 国家自然科学基金(61672001, 61702008, 11801362)，安徽省自然科学基金(1808085MF193)，安徽省高校自然科学研究项目(KJ2019A0538)

详细信息

作者简介:
殷志祥：男，1966年生，教授，研究方向为DNA计算和DNA自组装

唐震：男，1994年生，博士生，研究方向为DNA计算和DNA自组装

张强：男，1971年生，教授，研究方向为生物计算、智能机器人和医疗大数据处理

崔建中：男，1973年生，博士生，研究方向为DNA计算和DNA自组装

杨静：女，1980年生，副教授，研究方向为DNA计算和DNA自组装

王日晟：男，1993年生，博士生，研究方向为DNA计算和DNA自组装

赵寿为：女，1982年生，博士，研究方向为应用数学

张居丽：女，1982年生，博士，研究方向为计算数学

通讯作者:
唐震　1179145666@qq.com

中图分类号: TP301
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- 被引次数: 0
出版历程
- 收稿日期: 2019-10-28
- 修回日期: 2020-01-17
- 网络出版日期: 2020-02-19
- 刊出日期: 2020-06-22

NAND Gate Computational Model Based on the DNA Origami Template

1.
School of Mathematics, Physics and Statistics, Shanghai University of Engineering Science, Shanghai 201620, China
2.
School of Mathematics and Big Data, Anhui University of Science and Technology, Huainan 232001, China
3.
School of Computer Science and Technology, Dalian University of Technology, Dalian 116024, China
4.
Department of Computer, Huainan Union University, Huainan 232001, China

Funds: The National Natural Science Foundation of China (61672001, 61702008, 11801362), The Natural Science Foundation of Anhui Province (1808085MF193), The Natural Science Research Project of Universities in Anhui Province (KJ2019A0538)

摘要

摘要: 与非门(NAND)的本质是与门(AND)和非门(NOT)的叠加，先进行与运算，再进行非运算，它是建立DNA计算机的基础。为了实现与非门的计算，该文在DNA折纸基底上建立了一个与非门计算模型，逻辑值的输入是通过在DNA折纸基底上发生有向的杂交链式反应(HCR)来完成的，输入链先经过与门区域再经过非门区域，最后通过DNA折纸基底上是否还保留纳米金颗粒来显示计算结果的真假。利用Visual DSD对该计算模型进行仿真模拟，显示该计算模型具有较好的可行性。
- DNA计算 /
- DNA折纸术 /
- 与非门
Abstract: The essence of NAND gate is the superposition of AND gate and NOT gate. The AND gate operation is performed first, and then the NOT gate is performed. It is the basis of the DNA computer. In order to realize the computing of NAND gate, a NAND gate computational model is established based on the DNA origami template. The inputs of the logic value are completed by the Hybridization Chain Reaction (HCR) on the DNA origami template. The input strands first react with the AND gate region and then react with the NOT gate region. The result of the reaction is shown by dynamically separation of the gold nanoparticles on the DNA origami template. The simulation of the model through Visual DSD shows that the system has the advantages of high feasibility.
- DNA computing /
- DNA origami /
- NAND gate

HTML全文

图 1 杂交链式反应基本反应原理

下载: 全尺寸图片幻灯片

图 2 构建好的折纸基底示意图

下载: 全尺寸图片幻灯片

图 3 输入链示意图

下载: 全尺寸图片幻灯片

图 4 输入A=0, B=0后的结果示意图

下载: 全尺寸图片幻灯片

图 5 输入A=1, B=0后的结果示意图

下载: 全尺寸图片幻灯片

图 6 输入A=0, B=1后的结果示意图

下载: 全尺寸图片幻灯片

图 7 输入A=1, B=1后的结果示意图

下载: 全尺寸图片幻灯片

图 8 仿真模拟数据图

下载: 全尺寸图片幻灯片

图 9 最终产物的DNA链示意图

下载: 全尺寸图片幻灯片

表 1 与非门真值表

A 0 0 1 1
B 0 1 0 1
F 1 1 1 0

下载: 导出CSV

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