Abstract: A weighted estimation method based on the Time Delay Difference (TDD) variance is proposed with regard to the problem of TDD estimation of unknown source. This method utilizes the TDD of the target radiation signal frequency unit and the TDD of the noise frequency unit with respective characteristics of being stable and random to weight TDD estimation results of each frequency unit, enhancing the TDD estimation results of signal frequency unit, and achieving the TDD estimation of unknown source. The simulation results show that, compared with the conventional cross-correlation method, the estimation performance of this method is improved 3 dB. The theoretical analysis and simulation results both show that the robustness of this method is better than the conventional cross-correlation method.