Abstract: This paper proposes an interference-aware joint resource allocation scheme for relay-enhanced multicell networks with universal frequency reuse and the coexistence of different communication modes. The design of resource allocation is formulated as a non-linear combinatorial optimization issue with the objective of maximizing the overall system throughput, subject to interference and noise impairments, and individual power constraints at both Base Stations (BSs) and Relay Stations (RSs). To reduce the computational complexity, an inter-cell interference-based scheduling algorithm is proposed to address the user and relay pairing issue. Furthermore, a signomial programming-based optimal power allocation algorithm and a suboptimal minimal energy-consumption power allocation algorithm are devised as well. Numerical results indicate that the proposed algorithms approach to the optimal resource allocation, so that the system performance can be significantly improved in terms of network throughput and energy efficiency.