Abstract: Frequency reuse, as an efficient strategy to improve Cell-Edge User (CEU) performance, has already been well studied. However, improving spectral efficiency, as well as enhancing performance for CEU, is still left for an open research issue, especially for Orthogonal Frequency Division Multiple Access (OFDMA)-based 4th generation (4G) systems. Hence, a frequency reuse scheme which improves CEU performance by inter-cell interference mitigation is proposed for OFDMA systems here. In the meantime, to achieve a frequency reuse factor near 1, different frequency reuse strategies are assigned to cell-edge and cell-center due to the discrepancy between them. Simulation results demonstrate that, compared with full frequency reuse without frequency planning, the proposed frequency reuse scheme improves system throughput and CEU throughput significantly.