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基于DNA折纸订书钉链折叠的信息加密策略

侯晓玲 田卓立 王建榜 王丽华 李江 张继超 柳华杰

侯晓玲, 田卓立, 王建榜, 王丽华, 李江, 张继超, 柳华杰. 基于DNA折纸订书钉链折叠的信息加密策略[J]. 电子与信息学报, 2024, 46(9): 3771-3776. doi: 10.11999/JEIT231434
引用本文: 侯晓玲, 田卓立, 王建榜, 王丽华, 李江, 张继超, 柳华杰. 基于DNA折纸订书钉链折叠的信息加密策略[J]. 电子与信息学报, 2024, 46(9): 3771-3776. doi: 10.11999/JEIT231434
HOU Xiaoling, TIAN Zhuoli, WANG Jianbang, WANG Lihua, LI Jiang, ZHANG Jichao, LIU Huajie. A DNA Origami Cryptography Scheme Based on Staple Folding[J]. Journal of Electronics & Information Technology, 2024, 46(9): 3771-3776. doi: 10.11999/JEIT231434
Citation: HOU Xiaoling, TIAN Zhuoli, WANG Jianbang, WANG Lihua, LI Jiang, ZHANG Jichao, LIU Huajie. A DNA Origami Cryptography Scheme Based on Staple Folding[J]. Journal of Electronics & Information Technology, 2024, 46(9): 3771-3776. doi: 10.11999/JEIT231434

基于DNA折纸订书钉链折叠的信息加密策略

doi: 10.11999/JEIT231434
基金项目: 国家重点研发计划(2020YFA0908900),上海市基础研究特区计划
详细信息
    作者简介:

    侯晓玲:女,博士生,研究方向为DNA计算和DNA自组装

    田卓立:女,硕士生,研究方向为DNA器件和DNA自组装

    王建榜:男,研究员,研究方向为DNA器件和DNA自组装

    王丽华:女,研究员,研究方向为生物传感和DNA自组装

    李江:男,研究员,研究方向为DNA分子机器和DNA自组装

    张继超:男,副研究员,研究方向为同步辐射X射线成像

    柳华杰:男,教授,研究方向为DNA计算和DNA自组装

    通讯作者:

    柳华杰 liuhuajie@tongji.edu.cn

  • 中图分类号: TP301

A DNA Origami Cryptography Scheme Based on Staple Folding

Funds: The National Key R&D Program of China (2020YFA0908900), Shanghai Pilot Program for Basic Research
  • 摘要: DNA折纸结构是蕴含复杂序列折叠信息的纳米结构,为发展具有超大密钥空间的信息加密技术提供了新思路。该文设计了一种能够充分发挥DNA折纸结构信息特征的信息加密策略,与先前利用DNA折纸骨架链折叠的思路不同,该文基于订书钉链集合的非线性组合特征,提出通过探索其更为广阔的折叠多样性来实现更大的密钥空间。该策略的密钥空间计算模型分解为订书钉链的结合域模式、协同折叠以及独立性3个因素,分别考虑了订书钉链的链内区段分布性、链间排布多样性以及序列特异性。以上3种因素的组合,使单位几何空间内DNA折纸的折叠多样性更有效地转化为密钥空间。该策略是一种基于生物分子热力学的加密方式,为扩展信息安全的应用场景提供了新的可能。
  • 图  1  DNA折纸的信息编码方式

    图  2  发送方使用骨架链密钥进行加密

    图  3  分别使用正确及错误的骨架链密钥进行解密

    图  4  订书钉链的结合模式

    图  5  订书钉链的协同折叠

    图  6  订书钉链的序列独立性

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出版历程
  • 收稿日期:  2023-12-28
  • 修回日期:  2024-07-16
  • 网络出版日期:  2024-07-24
  • 刊出日期:  2024-09-26

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