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基于模型的帕金森病闭环深部脑刺激效果指标研究

赵德春 陈欢 沈利豪 焦书洋 蒋宇皓

赵德春, 陈欢, 沈利豪, 焦书洋, 蒋宇皓. 基于模型的帕金森病闭环深部脑刺激效果指标研究[J]. 电子与信息学报. doi: 10.11999/JEIT211516
引用本文: 赵德春, 陈欢, 沈利豪, 焦书洋, 蒋宇皓. 基于模型的帕金森病闭环深部脑刺激效果指标研究[J]. 电子与信息学报. doi: 10.11999/JEIT211516
ZHAO Dechun, CHEN Huan, SHEN Lihao, JIAO Shuyang, JIANG Yuhao. Research on Effect Index of Closed-loop Deep Brain Stimulation in Parkinson's Disease Based on Model[J]. Journal of Electronics & Information Technology. doi: 10.11999/JEIT211516
Citation: ZHAO Dechun, CHEN Huan, SHEN Lihao, JIAO Shuyang, JIANG Yuhao. Research on Effect Index of Closed-loop Deep Brain Stimulation in Parkinson's Disease Based on Model[J]. Journal of Electronics & Information Technology. doi: 10.11999/JEIT211516

基于模型的帕金森病闭环深部脑刺激效果指标研究

doi: 10.11999/JEIT211516
基金项目: 重庆市自然科学基金(cstc2018jcyjAX0163, cstc2019jcyj-msxmX0275),中国博士后基金(2021MD703941)
详细信息
    作者简介:

    赵德春:男,博士,教授,研究方向为脑机接口

    陈欢:女,硕士生,研究方向为帕金森病深部脑刺激

    沈利豪:男,硕士生,研究方向为运动想象分类算法

    焦书洋:男,硕士生,研究方向为脑机接口

    蒋宇皓:男,博士,讲师,研究方向为脑科学认知

    通讯作者:

    赵德春 zhaodc@cqupt.edu.cn

  • 中图分类号: Q811.4; R742.5

Research on Effect Index of Closed-loop Deep Brain Stimulation in Parkinson's Disease Based on Model

Funds: The Natural Science Foundation of Chongqing China (cstc2018jcyjAX0163, cstc2019jcyj-msxmX0275), China Postdoctoral Science Foundation (2021MD703941)
  • 摘要: 随着人口老龄化的加重,多发于中老年人的帕金森病(PD)将给社会带来沉重的压力。然而基于模型的闭环深部脑刺激(DBS)治疗PD的研究中刺激效果评估指标单一且不直观,因此该文提出统一帕金森病评分量表(UPDRS)类估计(SUE)。丘脑底核β频带(13~35 Hz)的异常振荡已被证明与PD运动障碍密切相关,该文首先验证了β频带在刺激与未刺激状态下的功率变化对计算模型与闭环深部脑刺激(DBS)算法的可行性。然后统计分析了β爆发在时域的分布情况,并根据时间长度将β爆发二分类为长爆发与短爆发。由于临床上采用统一帕金森病评分量表(UPDRS)对PD的治疗效果进行评价,所以将β爆发的时域特性与UPDRS评分进行对比,并结合β爆发的二分类结果提出了估计刺激疗效的指标SUE。实验结果表明SUE与β爆发的持续时间有较强的相关性,能很好地模拟UPDRS在刺激状态与未刺激状态下的变化,为今后基于模型的闭环DBS研究奠定了基础。
  • 图  1  皮层-基底节-丘脑网络模型

    图  2  LFP中β带功率谱密度

    图  3  闭环DBS刺激流程

    图  4  65%分位阈值下β爆发时域图(Patient 2)

    图  5  不同状态下β频带的功率变化

    图  6  β爆发的分布情况

    图  7  65%分位下的β爆发分布

    图  8  持续时间与SUE之间的相关性

    图  9  不同状态下的SUE

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出版历程
  • 收稿日期:  2021-12-15
  • 录用日期:  2022-03-03
  • 修回日期:  2022-02-24
  • 网络出版日期:  2022-03-08

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