基于DNA链置换的两位格雷码减法器分子电路设计

王延峰; 张桢桢; 王盼如; 孙军伟

doi:10.11999/JEIT190880

基于DNA链置换的两位格雷码减法器分子电路设计

doi: 10.11999/JEIT190880

郑州轻工业大学电气信息工程学院郑州 450002

基金项目: 国家重点研发计划中美政府间合作项目(2017YFE0103900)，国家自然科学基金河南联合基金(U1804262)，国家自然科学基金重点项目(61632002)，中原千人计划(204200510003)，食管癌防治国家重点实验室开放基金(K2020-0010, K2020-0011)

详细信息

作者简介:
王延峰：男，1973年生，教授，研究方向为生物启发计算

张桢桢：女，1994年生，硕士生，研究方向为生物启发计算

王盼如：女，1994年生，博士生，研究方向为生物启发计算

孙军伟：男，1984年生，副教授，研究方向为生物启发计算

通讯作者:
孙军伟　junweisun@yeah.net

中图分类号: TP 301
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出版历程
- 收稿日期: 2019-11-04
- 修回日期: 2020-06-07
- 网络出版日期: 2020-07-11
- 刊出日期: 2020-10-13

Molecular Circuit Design of Two-bit Gray Code Subtracter Based on DNA Strand Displacement

School of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou 450002, China

Funds: The National Key R and D Program of China for International S and T Cooperation Projects (2017YFE0103900), The Joint Funds of the National Natural Science Foundation of China (U1804262), The State Key Program of National Natural Science of China (61632002), The Central Plains Thousand Talents Program (204200510003), The Open Fund of State Key Laboratory of Esophageal Cancer Prevention and Treatment (K2020-0010, K2020-0011)

摘要

摘要: DNA链置换技术具有自发性、并行性、可编程性、动态级联性的特点，在DNA计算中占据重要的地位。DNA链置换技术被广泛的应用于解决数学问题，该文采用格雷码编码方式结合DNA链置换技术设计了两位减法器，扩展DNA减法运算。最后利用Visual DSD软件模拟两位减法器，该电路达到预期的功能，且具有并行性和可扩展性，可与其他生化电路结合使用。
- 分子电路 /
- DNA链置换 /
- 格雷码 /
- 减法器
Abstract: DNA strand displacement technology has the characteristics of spontaneity, parallelism, programmability and dynamic cascade, which is widely used to solve mathematical problems. In this paper, a two-bit subtracter is designed by using Gray code encoding and DNA strand displacement technology to extend the operation of DNA subtraction. Finally, Visual DSD software is used to simulate the two-bit subtracter. The circuit, with the strong parallelism and expansibility, achieves the expected function. It can be used in combination with other biochemical circuits.
- Molecular circuit /
- DNA strand displacement /
- Gray code /
- Subtracter

HTML全文

图 1 DNA链置换反应的过程机理

下载: 全尺寸图片幻灯片

图 2 两位格雷码减法器seesaw门

下载: 全尺寸图片幻灯片

图 3 两位减法器seesaw双轨分子电路

下载: 全尺寸图片幻灯片

图 4 DNA链置换的反应过程机理示意图

下载: 全尺寸图片幻灯片

5 两位格雷码减法器仿真图

下载: 全尺寸图片幻灯片

表 1 两位减法器操作运算的真值表

X₂X₁/减数	U₂U₁/被减数	S₂S₁/差值	B₂/高位借位	X₂X₁/减数	U₂U₁/被减数	S₂S₁/差值	B₂/高位借位
00	00	00	0	11	00	11	0
00	01	10	1	11	01	01	0
00	11	11	1	11	11	00	0
00	10	01	1	11	10	10	1
01	00	01	0	10	00	10	0
01	01	00	0	10	01	11	0
01	11	10	1	10	11	01	0
01	10	11	1	10	10	00	0

下载: 导出CSV

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