基于阻抗检测微传感技术的皮肤渗透性评估方法

赵湛; 卢飞; 王辰硕; 赵荣建; 杜利东; 方震

doi:10.11999/JEIT171242

基于阻抗检测微传感技术的皮肤渗透性评估方法

doi: 10.11999/JEIT171242

赵湛^{*①②卢飞},
卢飞,
王辰硕,
赵荣建,
杜利东¹,
方震

(中国科学院电子学研究所北京 100190) ②(中国科学院大学北京 100049)

基金项目:

国家自然科学基金(61431019)，北京市自然科学基金(Z160002)

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- 被引次数: 0
出版历程
- 收稿日期: 2017-12-28
- 修回日期: 2018-03-15
- 刊出日期: 2018-08-19

Evaluation of Skin Permeability Based on Impedance Detection by Microsensor Technology

(Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, China)

Funds:

The National Natural Science Foundation of China (61431019), The Key Project of Beijing Municipal Natural Science Foundation (Z160002)

摘要

摘要: 基于宏电极的单频皮肤阻抗测量是利用阻抗进行皮肤渗透性研究的传统方法之一，其存在误差大、灵敏度低且不易于设备集成的缺点。由此，该文通过分析皮肤的分层生理结构以及皮肤渗透性与角质层(SC)阻抗的关系，设计了基于柔性非对称叉指微电极的皮肤阻抗传感器，构建了RCW分层阻抗模型，实现了对人体角质层阻抗的检测分析。实验结果表明，传感器输出的阻抗模值和模型拟合参数可用作表征皮肤渗透性的重要指标。该方法可用于区分不同个体的皮肤渗透性，为人体生理生化检测相关的可穿戴设备参数调节提供依据。
- 可穿戴设备 /
- 皮肤阻抗 /
- 叉指微电极 /
- 皮肤渗透能力 /
- 阻抗模型
Abstract: Traditionally, skin permeability evaluation, which is realized by impedance detected at a certain frequency based on macro electrodes, has the disadvantages of large measurement error, low sensitivity and difficulty in integration. In order to resolve this problem, a flexible non-symmetric interdigital microsensor is designed by analyzing the layered structure of skin and the relationship between skin permeability and impedance of Stratum Corneum(SC). The impedance of SC is measured and analyzed based on the RCW-layered impedance model. It is illustrated that the impedance magnitude of microsensor output and model fitting parameters can be used as the important indicators to evaluate skin permeability. It is proved that the developed sensor can be applied to distinguishing the different individuals skin permeability, and it strongly supports the adjustment of wearable devices related to human physiological and biochemical detection.
- Wearable device /
- Skin impedance /
- Interdigital microelectrode /
- Skin permeability /
- Impedance model

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参考文献(22)

KIM J, CAMPBELL A S, and WANG J. Wearable non-invasive epidermal glucose sensors: A review0[J]. Talanta, 2017, 177: 163-170. doi: 10.1016/j.talanta.2017.08.077.

赵湛, 韩璐, 方震, 等. 基于可穿戴设备的日常压力状态评估研究[J]. 电子与信息学报, 2017, 39(11): 2669-2676. doi: 10.11999/JEIT170120. ZHAO Zhan, HAN Lu, FANG Zhen, et al. Research on daily stress detection based on wearable device[J]. Journal of Electronics Information Technology, 2017, 39(11): 2669-2676. doi: 10.11999/JEIT170120.

KENR Y, YEO J C, and LIM C T. Emerging flexible and wearable physical sensing platform for healthcare and biomedical applications[J]. Microsystems Nanoengineering, 2016, 2, 16043. doi: 10.1038/micronano.2016.43.

KRISHNAN S, SHI Y, CHADWEBB R, et al. Multimodal epidermal devices for hydration monitoring[J]. Microsystems Nanoengineering, 2017, 3, 17014. doi: 10.1038/micronano. 2017.14.

MCCORMICK C, HEATH D, and CONNOLLY P. Minimally Invasive Sensing[M]. Rijeka, Croatia, 2011: 355-382.

VENTRELLI L, MARSILIO S L, and BARILLARO G. Microneedles for transdermal biosensing: Current picture and future direction[J]. Advanced Healthcare Materials, 2015, 4(17): 2606-2640. doi: 10.1002/adhm.201500450.

EASTMAN R C, CHASE H P, BUCKINGHAM B, et al. Use of the GlucoWatch biographer in children and adolescents with diabetes[J]. Pediatric Diabetes, 2002, 3(3): 127-34. doi: 10.1034/j.1399-5448.2002.30302.x.

YOSHIMATSU H, ISHII K, KONNO Y, et al. Prediction of human percutaneous absorption from in vitro and in vivo animal experiments[J]. International Journal of Pharmaceutics, 2017, 534(1): 348-355. doi: 10.1016/j.ijpharm. 2017.10.048.

WHITE E A, HORNE A, RUNCIMAN J, et al. On the correlation between single-frequency impedance measurements and human skin permeability to water[J]. Toxicology in Vitro, 2011, 25(8): 2095-2104. doi: 10.1016/ j.tiv.2011.09.011.

SCHWINGENSCHUH S, SCHARFETTER H, MARTINSEN O G, et al. Assessment of skin permeability to topically applied drugs by skin impedance and admittance[J]. Physiological Measurement, 2017, 38(11): N138-N150. doi: 10.1088/1361-6579/aa904e.

MARTINSEN ? G, GRIMNES S, and HAUG E. Measuring depth depends on frequency in electrical skin impedance measurements[J]. Skin Research Technology, 2010, 5(3): 179-181. doi: 10.1111/j.16000846.1999.tb00128.x.

CLEMENTE F, ARPAIA P, and MANNA C. Characterization of human skin impedance after electrical treatment for transdermal drug delivery[J]. Measurement, 2013, 46(9): 3494-3501. doi: 10.1016/j.measurement.2013.06. 033.

LI Dachao, PU Zhihua, LIANG Wenshuai, et al. Non-invasive measurement of normal skin impedance for determining the volume of the transdermally extracted interstitial fluid[J]. Measurement, 2015, 62: 215-221. doi: 10.1016/j.measurement. 2014.11.015.

KALIA Y N and GUY R H. The electrical characteristics of human skin in vivo[J]. Pharmaceutical Research, 1995, 12(11): 1605-1613. doi: 10.1023/A:1016228730522.

IVANIC R, NOVOTNY I, REHACEK V, et al. Thin film non-symmetric microelectrode array for impedance monitoring of human skin[J]. Thin Solid Films, 2003, 433(1): 332-336. doi: 10.1016/S0040-6090(03)00389-4.

MAMISHEV A V, SUNDARA-RAJAN K, YANG Fumin, et al. Interdigital sensors and transducers[J]. Proceedings of the IEEE, 2004, 92(5): 808-845. doi: 10.1109/JPROC.2004. 826604.

杨鹏飞, 彭春荣, 张海岩, 等. SOI微型电场传感器的设计与测试[J]. 电子与信息学报, 2011, 33(11): 2771-2774. doi: 10.3724/SP.J.1146.2010.01285. YANG Pengfei, PENG Chunrong, ZHANG Haiyan, et al. Design and testing of a SOI electric-field microsensor[J]. Journal of Electronics Information Technology, 2011, 33(11): 2771-2774. doi: 10.3724/SP.J.1146.2010.01285.

HUCLOVA S, BAUMANN D, TALARY M S, et al. Sensitivity and specificity analysis of fringing-field dielectric spectroscopy applied to a multi-layer system modelling the human skin[J]. Physics in Medicine Biology, 2011, 56(24): 7777-7793. doi: 10.1088/0031-9155/56/24/007.

GABRIEL S, LAU R W, and GABRIEL C. The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues[J]. Physics in Medicine Biology, 1996, 41(11): 2271-2293. doi: 10.1088/0031-9155/ 41/11/003.

BARONI A, BUOMMINO E, DE G V, et al. Structure and function of the epidermis related to barrier properties[J]. Clinics in Dermatology, 2012, 30(3): 257-262. doi: 10.1016/ j.clindermatol.2011.08.007.

BIRGERSSON U, BIRGERSSON E, ABERG P, et al. Non-invasive bioimpedance of intact skin: Mathematical modeling and experiments[J]. Physiological Measurement, 2011, 32(1): 1-18. doi: 10.1088/0967-3334/32/1/001.

SANDBY-M LLER J, POULSEN T, and WULF H C. Epidermal thickness at different body sites: relationship to age, gender, pigmentation, blood content, skin type and smoking habits[J]. Acta Dermato-Venereologica, 2003, 83(6): 410-413. doi: 10.1080/00015550310015419.

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