引脚约束的数字微流控生物芯片在线并行测试

许川佩; 陈春艳; 汪杰君

doi:10.11999/JEIT150095

引脚约束的数字微流控生物芯片在线并行测试

doi: 10.11999/JEIT150095

基金项目:

广西自然科学基金(2014GXNSFAA118398)和广西研究生教育创新计划(GDYCSZ201430)

计量
- 文章访问数: 1136
- HTML全文浏览量: 292
- PDF下载量: 436
- 被引次数: 0
出版历程
- 收稿日期: 2015-01-15
- 修回日期: 2015-05-12
- 刊出日期: 2015-09-19

Online Parallel Testing of Pin-constrained Digital Microfluidic Biochips

摘要

摘要: 随着数字微流控生物芯片在生化领域中的广泛应用，对芯片可靠性和制造成本的要求也越来越高，在线测试对于确保微流控生物芯片正常工作异常重要。该文针对引脚约束的数字微流控生物芯片，提出一种基于改进最大最小蚁群算法的在线并行测试方案，在满足各种约束条件的情况下，采用伪随机比例原则，建立禁忌判断策略，自适应地改变信息素的残留系数，实现引脚约束数字微流控生物芯片的在线并行测试。实验结果表明，该方法可以同时用于离线和在线测试，相对于单液滴离线和在线测试，可有效减少芯片的测试时间，提高了测试工作效率。
- 数字微流控芯片 /
- 并行测试 /
- 引脚约束 /
- 最大最小蚁群算法
Abstract: As digital microfluidic biochips are widely used in biochemical field, it highly demands the chip reliability and manufacturing costs. Online testing is an important method to ensure the normal work of the digital microfluidic biochips. In this paper, an online parallel testing scheme is proposed based on improved max-min ant colony algorithm for pin-constrained digital microfluidic biochips. The scheme uses pseudo-random-proportional rules, establishes a taboo judgment strategy, and changes the pheromone trail persistence adaptively to realize the online parallel testing of pin-constrained digital microfluidic biochips. The experiment results show that the proposed method can be used for both offline and online testing, and compared with the offline and online testing of the single droplet, the proposed method can effectively reduce the test time and improve the efficiency.
- Digital microfluidic biochips /
- Parallel testing /
- Pin-constrained /
- Max-min ant colony algorithm

HTML全文

参考文献(21)

Xu T and Chakrabarty K. Fault modeling and functional test methods for digital microfluidic biochips[J]. IEEE Transactions on Biomedical Circuits and Systems, 2009, 3(4): 241-253.

杨敬松, 姚振静, 宋燕星, 等. 数字微流控生物芯片布局的拟人遗传组合算法[J]. 计算机工程与应用, 2012, 48(31): 16-20.

Yang Jing-song, Yao Zhen-jing, Song Yan-xing, et al.. Personification and genetic combinational algorithm for placement problem of digital microfluidics-based biochips[J]. Computer Engineering and Applications, 2012, 48(31): 16-20.

Xu T and Chakrabarty K. Broadcast electrode-addressing and scheduling methods for pin-constrained digital microfluidic biochip[J]. IEEE Transactions on Computer- Aided Design of Integrated Circuits and Systems, 2011, 30(7): 986-999.

Luo Y and Chakrabarty K. Design of pin-constrained general-purpose digital microfluidic biochips[J]. IEEE Transactions Computer-Aided Design of Integrated Circuits and Systems, 2013, 32(9): 1307-1320.

Grissom D T, McDaniel J, and Brisk P. A low-cost field- programmable pin constrained digital microfluidic biochip[J]. IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, 2014, 33(11): 1657-1670.

Su F, Ozev S, and Chakrabarty K. Testing of droplet-based microelectrofluidics systems[C]. Proceedings IEEE International Test Conference, Charlotte, 2003: 1192-1200.

Su F, Ozev S, and Chakrabarty K. Test planning and test resource optimization for droplet-based microfluidic systems [J]. Journal of Electronic Testing: Theory and Applications, 2006, 22(2): 199-210.

Su F, Hwang W, Mukherjee A, et al.. Testing and diagnosis of realistic defects in digital microfluidic biochips[J]. Journal of Electronic Testing: Theory and Applications, 2007, 23(2/3): 219-233.

Xu T and Chakrabarty K. Paralled scan-like test and multiple-defect diagnosis for digital microfluidic biochips[J]. IEEE Transactions on Biomedical Circuits and Systtems, 2007, 1(2): 148-158.

张玲, 邝继顺, 林静, 等. 数字微流控生物芯片的并行在线测试[J]. 上海交通大学学报, 2013, 47(1): 98-102.

Zhang Ling, Kuang Ji-shun, Lin Jing, et al.. Parallel on-line testing for digital microfluidic biochip[J]. Jouranl of Shanghai Jiao Tong University, 2013, 47(1): 98-102.

张玲, 邝继顺, 梅军进, 等. 数字微流控生物芯片测试诊断过程分析和优化[J]. 计算机工程与科学, 2014, 36(3): 411-415.

Zhang Ling, Kuang Ji-shun, Mei Jun-jin, et al.. Analysis and optimization of test and diagnosis process for digital microfluidic biochip[J]. Computer Engineering and Science, 2014, 36(3): 411-415.

Su F, Ozev S, and Chakrabarty K. Concurrent testing of droplet-based microfluidic systems for multiplexed biomedical assays[C]. Proceedings IEEE International Test Conference, Charlotte, 2004: 883-892.

杨延庆, 李鹏飞, 何博. 求解TSP问题的改进最大最小蚁群算法[J]. 西安工程大学学报, 2010, 24(6): 818-821.

Yang Yan-qing, Li Peng-fei, and He Bo. The solution of TSP based on the improved max-min ant colony algorithm[J]. Journal of Xian Polytechnic University, 2010, 24(6): 818-821.

许川佩, 蔡震, 胡聪. 基于蚁群算法的数字微流控生物芯片在线测试路径优化[J]. 仪器仪表学报, 2014, 35(6): 1417-1424.

Xu Chuan-pei, Cai Zhen, and Hu Cong. On-line test path optimization for digital microfluidic biochips based on ant colony algorithm[J]. Chinese Journal of Scientific Instrument, 2014, 35(6): 1417-1424.

Royal M W, Jokerst N M, and Fair R B. Droplet-based sensing: Optical microresonator sensors embedded in digital electrowetting microfluidics systems[J]. IEEE Sensors Journal, 2013, 13(12): 4733-4742.

Su F, Hwang W, Mukherjee A, et al.. Defect-oriented testing and diagnosis of digital microfluidics-based biochips[C]. Proceedings IEEE International Test Conference, Austin, 2005: 1-10.

施引文献

资源附件(0)

访问统计