An Autonomic Energy-Saving Management Mechanism (AESMM) based on autonomic management is proposed for saving energy in wireless cellular networks. Energy-saving model is analyzed firstly, and then procedures of AESMM are introduced. As two key issues of AESMM, regional BS opposite-pair compensation method and autonomic intelligent optimization algorithm for coverage compensation are proposed. Objective is maximizing regional saving energy and meanwhile guaranteeing regional coverage and service quality. AESMM is simulated under WCDMA/HSDPA scenario. Comparing to other two methods adopted in the references, results show that AESMM can save maximal energy (about 17% of regional energy consumption) while keep regional coverage and service quality acceptable.