The issue of Co-Channel Interference (CCI) in the Orthogonal Frequency Division Multiplexing (OFDM) systems is studied in this paper. A time-domain estimation and elimination scheme of sinusoidal-modeled CCI is proposed based on the Minimum Mean Square Error (MMSE) criterion. It is proved by simulation that the proposed algorithm can suppress the CCI effectively. Compared with the existing scheme, the proposed time-domain method can avoid the interference leakage because of the time-to-frequency transformation, the dependence on channel estimation and the loss of useful data caused by directly erasing.