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Volume 44 Issue 1
Jan.  2022
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LI Jiaxin, CHEN Houjin, PENG Yahui, LI Yanfeng. Multi-Modal Pulmonary Mass Segmentation Network Based on Cross-Modal Spatial Alignment[J]. Journal of Electronics & Information Technology, 2022, 44(1): 11-17. doi: 10.11999/JEIT210710
Citation: LI Jiaxin, CHEN Houjin, PENG Yahui, LI Yanfeng. Multi-Modal Pulmonary Mass Segmentation Network Based on Cross-Modal Spatial Alignment[J]. Journal of Electronics & Information Technology, 2022, 44(1): 11-17. doi: 10.11999/JEIT210710

Multi-Modal Pulmonary Mass Segmentation Network Based on Cross-Modal Spatial Alignment

doi: 10.11999/JEIT210710
Funds:  The National Natural Science Foundation of China (62172029, 61872030, 61771039)
  • Received Date: 2021-07-15
  • Accepted Date: 2021-11-20
  • Rev Recd Date: 2021-10-20
  • Available Online: 2021-12-25
  • Publish Date: 2022-01-10
  • Most of the existing multi-modal segmentation methods are adopted on the co-registered multi-modal images. However, these two-stage algorithms of the segmentation and the registration achieve low segmentation performance on the modalities with remarkable spatial misalignment. To solve this problem, a cross-modal Spatial Alignment based Multi-Modal pulmonary mass Segmentation Network (MMSASegNet) with low model complexity and high segmentation accuracy is proposed. Dual-path Res-UNet is adopted as the backbone segmentation architecture of the proposed network for the better multi-modal feature extraction. Spatial Transformer Networks (STN) is applied to the segmentation masks from two paths to align the spatial information of mass region. In order to realize the multi-modal feature fusion based on the spatial alignment on the region of mass, the deformed mask and the reference mask are matrix-multiplied by the feature maps of each modality respectively. Further, the yielding cross-modality spatially aligned feature maps from multiple modalities are fused and learned through the feature fusion module for the multi-modal mass segmentation. In order to improve the performance of the end-to-end multi-modal segmentation network, deep supervision learning strategy is employed with the joint cost function constraining mass segmentation, mass spatial alignment and feature fusion. Moreover, the multi-stage training strategy is adopted to improve the training efficiency of each module. On the pulmonary mass datasets containing T2-Weighted-MRI(T2W) and Diffusion-Weighted-MRI Images(DWI), the proposed method achieved improvement on the metrics of Dice Similarity Coefficient (DSC) and Hausdorff Distance (HD).
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  • [1]
    ALAM F and RAHMAN S U. Challenges and solutions in multimodal medical image subregion detection and registration[J]. Journal of Medical Imaging and Radiation Sciences, 2019, 50(1): 24–30. doi: 10.1016/j.jmir.2018.06.001
    [2]
    HASKINS G, KRUGER U, and YAN Pingkun. Deep learning in medical image registration: A survey[J]. Machine Vision and Applications, 2020, 31(1/2): 8. doi: 10.1007/s00138-020-01060-x
    [3]
    ONG E P, CHENG Jun, WONG D W K, et al. A robust outliers’ elimination scheme for multimodal retina image registration using constrained affine transformation[C]. The TENCON 2018 - 2018 IEEE Region 10 Conference, Jeju, Korea (South), 2018: 425–429.
    [4]
    WANG Xiaoyan, MAO Lizhao, HUANG Xiaojie, et al. Multimodal MR image registration using weakly supervised constrained affine network[J]. Journal of Modern Optics, 2021, 68(13): 679–688. doi: 10.1080/09500340.2021.1939897
    [5]
    RUECKERT D, SONODA L I, HAYES C, et al. Nonrigid registration using free-form deformations: Application to breast MR images[J]. IEEE Transactions on Medical Imaging, 1999, 18(8): 712–721. doi: 10.1109/42.796284
    [6]
    DOLZ J, GOPINATH K, YUAN Jing, et al. HyperDense-Net: A hyper-densely connected CNN for multi-modal image segmentation[J]. IEEE Transactions on Medical Imaging, 2019, 38(5): 1116–1126. doi: 10.1109/TMI.2018.2878669
    [7]
    LI Jiaxin, CHEN Houjin, LI Yanfeng, et al. A novel network based on densely connected fully convolutional networks for segmentation of lung tumors on multi-modal MR images[C]. The 2019 International Conference on Artificial Intelligence and Advanced Manufacturing, Dublin, Ireland, 2019: 69.
    [8]
    CAI Naxin, CHEN Houjin, LI Yanfeng, et al. Adaptive weighting landmark-based group-wise registration on lung DCE-MRI images[J]. IEEE Transactions on Medical Imaging, 2021, 40(2): 673–687. doi: 10.1109/TMI.2020.3035292
    [9]
    ZHU Wentao, MYRONENKO A, XU Ziyue, et al. NeurReg: Neural registration and its application to image segmentation[C]. 2020 IEEE Winter Conference on Applications of Computer Vision (WACV), Snowmass, USA, 2020: 3606–3615.
    [10]
    LIU Jie, XIE Hongzhi, ZHANG Shuyang, et al. Multi-sequence myocardium segmentation with cross-constrained shape and neural network-based initialization[J]. Computerized Medical Imaging and Graphics, 2019, 71: 49–57. doi: 10.1016/j.compmedimag.2018.11.001
    [11]
    XU R S, ATHAVALE P, LU Yingli, et al. Myocardial segmentation in late-enhancement MR images via registration and propagation of cine contours[C]. The 10th International Symposium on Biomedical Imaging, San Francisco, USA, 2013: 856–859.
    [12]
    ZHUANG Xiahai. Multivariate mixture model for myocardial segmentation combining multi-source images[J]. IEEE Transactions on Pattern Analysis and Machine Intelligence, 2019, 41(12): 2933–2946. doi: 10.1109/TPAMI.2018.2869576
    [13]
    CHARTSIAS A, PAPANASTASIOU G, WANG Chengjia, et al. Disentangle, align and fuse for multimodal and semi-supervised image segmentation[J]. IEEE Transactions on Medical Imaging, 2021, 40(3): 781–792. doi: 10.1109/TMI.2020.3036584
    [14]
    JADERBERG M, SIMONYAN K, ZISSERMAN A, et al. Spatial transformer networks[C]. The 28th International Conference on Neural Information Processing Systems, Montreal, Canada, 2015: 2017–2025.
    [15]
    RONNEBERGER O, FISCHER P, and BROX T. U-Net: Convolutional networks for biomedical image segmentation[C]. The 18th International Conference on Medical Image Computing and Computer-Assisted Intervention, Munich, Germany, 2015.
    [16]
    LEE C Y, XIE Saining, GALLAGHER P W, et al. Deeply-supervised nets[C]. The 18th International Conference on Artificial Intelligence and Statistics (AISTATS), San Diego, USA, 2015.
    [17]
    KHANNA A, LONDHE N D, GUPTA S, et al. A deep Residual U-Net convolutional neural network for automated lung segmentation in computed tomography images[J]. Biocybernetics and Biomedical Engineering, 2020, 40(3): 1314–1327. doi: 10.1016/j.bbe.2020.07.007
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