Abstract: By employing MMSE (Minimal Mean Squared Error) criteria, the multi-user transceivers in this paper are optimized by adjusting their signatures and demodulations according to interferences around, which can reduce at most the co-interferences from users and minimize the lower bound of MMSE. During the design process, the striking improvements in both convergence and low-complexity are achieved by using matrix-blocking computation theory. And in practice, the designed signature assemble perform rather well than that by capacity-maximizing signature design method (Rose etc.2002) under the additive white Gaussian noise channel. Finally, some simulation results are also provided as proof.