Methods for Measuring Single-Cell Structural and Electrical Properties

LIANG Hongyan; CHEN Deyong; WANG Junbo; CHEN Jian

doi:10.11999/JEIT211459

Volume 44 Issue 8

Aug. 2022

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Article Navigation > Journal of Electronics & Information Technology > 2022 > 44(8): 2966-2976

LIANG Hongyan, CHEN Deyong, WANG Junbo, CHEN Jian. Methods for Measuring Single-Cell Structural and Electrical Properties[J]. Journal of Electronics & Information Technology, 2022, 44(8): 2966-2976. doi: 10.11999/JEIT211459

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LIANG Hongyan, CHEN Deyong, WANG Junbo, CHEN Jian. Methods for Measuring Single-Cell Structural and Electrical Properties[J]. Journal of Electronics & Information Technology, 2022, 44(8): 2966-2976. doi: 10.11999/JEIT211459

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Methods for Measuring Single-Cell Structural and Electrical Properties

doi: 10.11999/JEIT211459

LIANG Hongyan^{1, 2},
CHEN Deyong^{1, 2, 3},
WANG Junbo^{1, 2, 3},
CHEN Jian^{1, 2, 3
,
,}

1.
State Key Laboratory of Transducer Technology, Aerospace Information Research Institute of Chinese Academy of Sciences, Beijing 100190, China
2.
School of Electronic, Electrical and Communication Engineering of University of Chinese Academy of Sciences, Beijing 100049, China
3.
School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China

Funds: The National Natural Science Foundation of China (61825107, 61922079, 62121003)

Received Date: 2021-12-08
Rev Recd Date: 2022-03-17

Available Online: 2022-04-16

Publish Date: 2022-08-17

Abstract

Abstract

Single-cell intrinsic biophysical properties including structural properties (e.g., cellular diameter and nuclear diameter) and electrical properties (e.g., specific membrane capacitance and cytoplasmic conductivity) have been applied to cell subtype classifications, and cell status evaluations are promising in biomedical research and clinical diagnosis. Different types of single-cell structural and electrical properties detection methods are reviewed in this paper, then fixed and flow methods and microfluidic methods are introduced. The working principles, developments, main advantages and disadvantages of these methods are summarized, and the challenges and future research opportunities for measurements of single-cell structural and electrical properties are discussed.
- Single-cell analysis,
- Structural properties,
- Electrical properties,
- Microfluidics

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References(80)

References

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