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Volume 44 Issue 6
Jun.  2022
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HUANG Chun, GUO Yifei, ZHANG Xinya, SUN Junwei, WANG Yingcong, LI Panlong, WANG Yanfeng. Design of Four-bit Subtracter Using Excess-3 Code Rules Based on DNA Domain Coding[J]. Journal of Electronics & Information Technology, 2022, 44(6): 2110-2118. doi: 10.11999/JEIT210216
Citation: HUANG Chun, GUO Yifei, ZHANG Xinya, SUN Junwei, WANG Yingcong, LI Panlong, WANG Yanfeng. Design of Four-bit Subtracter Using Excess-3 Code Rules Based on DNA Domain Coding[J]. Journal of Electronics & Information Technology, 2022, 44(6): 2110-2118. doi: 10.11999/JEIT210216

Design of Four-bit Subtracter Using Excess-3 Code Rules Based on DNA Domain Coding

doi: 10.11999/JEIT210216
Funds:  The National Key R & D Program of China (2017YFE0103900), The National Natural Science Foundation of China (U1804262, 61603348, 61632002, 61702463), The Zhongyuan Thousand Talents Program (204200510003), The Open Fund of State Key Laboratory of Esophageal Cancer Prevention and Treatment (K2020-0010, K2020-0011), The Technology Program of Henan Province (202102310202)
  • Received Date: 2021-03-15
  • Rev Recd Date: 2021-07-18
  • Available Online: 2021-07-27
  • Publish Date: 2022-06-21
  • The design of DNA molecular logic circuits is an important direction in the field of DNA computing. Considering the problems of high complexity and slow response time for dual rail molecular logic circuits, a new strategy based on DNA domain coding is proposed in this study, which is used to construct molecular logic circuits. In this paper, the operation modules of “multiple-inputs-one-output” are introduced, and the fan-out gates and amplification gates are also constructed. Then, the molecular logic circuit to solve four-bits-square-rooting is formed with these logic computing modules designed in this paper. Compared with the four-bit square root circuit under the classical dual-track strategy, the number of reactants is reduced from 130 to 61, and the system response time is reduced to 1 / 24 of the dual-track strategy, which simplifies greatly the complexity of the circuit and improves the response speed of the system. It verifies further the effectiveness of the domain coding strategy in the design of molecular logic circuits. In order to analyze further the design concept for large-scale complicated molecular logic circuits based on domain coding, a four-bit excess-3 code subtracter is constructed, which provides more solutions for designing large-scale functional DNA logic circuits.
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