Basic Logic Gates Design Based on DNA and Restriction Endonuclease

Juan LIU; Wenbin XIE; Gaiying WANG; Minli TANG

doi:10.11999/JEIT190846

Volume 42 Issue 6

Jun. 2020

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Juan LIU, Wenbin XIE, Gaiying WANG, Minli TANG. Basic Logic Gates Design Based on DNA and Restriction Endonuclease[J]. Journal of Electronics & Information Technology, 2020, 42(6): 1332-1339. doi: 10.11999/JEIT190846

Citation:

Juan LIU, Wenbin XIE, Gaiying WANG, Minli TANG. Basic Logic Gates Design Based on DNA and Restriction Endonuclease[J]. Journal of Electronics & Information Technology, 2020, 42(6): 1332-1339. doi: 10.11999/JEIT190846

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Basic Logic Gates Design Based on DNA and Restriction Endonuclease

doi: 10.11999/JEIT190846

1.
School of Aerospace Engineering, Xiamen University, Xiamen 361102, China
2.
School of Informatics, Xiamen University, Xiamen 361005, China
3.
Shenzhen Research Institute, Xiamen University, Shenzhen 518057, China

Funds: The National Natural Science Foundation of China (61772441, 61872309), The National Key R&D Program of China (2017YFE0130600)

Received Date: 2019-11-01
Rev Recd Date: 2020-04-24

Available Online: 2020-05-13

Publish Date: 2020-06-22

Abstract

Abstract

Due to the natural characteristics of specificity, high parallelism and miniaturization of DNA molecules, it exhibits strong parallel computing power and data storage capability in information processing. In this study, restriction endonuclease with specific recognition function are introduced into DNA strand displacement as the input of the DNA circuit. The YES gate, NOT gate and AND gate are designed by controlling the generation and removal of the toehold. The logic model is simulated by Visual DSD, and the design is verified by PolyacrylAmide Gel Electrophoresis(PAGE) experiments. Compared with previous molecular logic gates, this design has a quick response, simple operation, and good scalability, which provides the possibility for the design of large-scale circuits.
- Molecular logic computation,
- DNA strand displacement,
- Restriction endonuclease,
- Basic logic gates

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References(19)

References

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