Abstract: In order to compensate the outage cell autonomously, this paper derives a solution for Cell Outage Compensation (COC) in Self-Organizing Networks (SON) which is based on the joint adjustment of power and tilt. Firstly, the paper takes the power and tilt as the optimization objects. Then it defines the rational objectives and the evaluation index of the COC, and analyzes the optimization model. Finally, the compensation mechanism based on the Genetic optimization Algorithm (GA) is proposed. The simulation results under the Time Division Long Term Evolution (TD-LTE) scenario show that the proposed solution is better than other three methods in terms of the coverage, interference, and throughput.