Abstract: In order to apply Visible Light Communication (VLC) to indoor positioning, based on the Received Signal Strength (RSS) positioning technology, a scheme namely MLED-RSS positioning algorithm, utilizing multiple LED transmitters to achieve indoor positioning is proposed in this paper. In the proposed scheme, the impact of topology on positioning performance is fully considered, three LEDs are reasonably selected from the multiple LEDs deployed in the room as transmitted nodes to provide position coordinates, and then the improved trilateration method is used to obtain the target location information. MLED-RSS positioning algorithm can effectively solve the block or shadow effect existing in indoor visible location. Simulation results show that the MLED-RSS positioning algorithm can achieve high localization accuracy.