微阵列光寻址生化传感器系统性能研究
Research of properties on the bio-chemical micro-array light addressable potentiometric sensor system
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摘要: 该文介绍一种基于电解质溶液-绝缘层-半导体(EIS)结构的光、机、电一体化的微阵列光寻址电位传感器系统(LAPS)。文中研讨了LAPS的基本原理和微阵列光寻址电位传感器系统的制造。通过实验证明了芯片厚度、调制频率、曲线线性度对系统性能的影响,获得多种生化参数的光寻址测试结果。Abstract: This paper describes a kind of micro-array Light Addressable Potentionietric Sen-sor(LAPS) system based on the Electrolyte-Insulator-Semiconductor (EIS) structure, in which electronic technology, optical technology and mechanical technology are applied. The mecha-nism of the LAPS is investigated and a trial specimen of the LAPS is developed ? The research work finds how the thickness of the chip, the linearity of the I-V curve and frequency affect the performance of the LAPS system, and obtains testing results of urea, penicillin and pH value.
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D.G. Hafeman, J. W. Parce, H. M. McConnell, Light-addressable potentiometric sensor for biochemical system.[J]. Science.1988,240:1182-[2]梁卫国,韩泾鸿,光寻址电位传感器的机理研究,半导体光电,2001,22(8),184-187.[3]M. Sartore, M. Adami, C. Nicolini, Computer simulation and optimization of a light addressable potentiometric sensor, Biosensors Bioeletronics 1992, 8(7), 57-64.[4]M. Sarore, M. Adami, C. Nicolini, L. Bousse, S. Mostarshed, D. Hafeman, Minority carrier diffusion length effects on light-addressable potentiometric sensor (LAPS) devices, Sensors and Actuators A, 1992, (32), 431-436.[5]L. Bousse, S Mostarshed, D. Hafeman, M. Sarore, M. Adami, C. Nicolini, Investigation of carrier transport through silicon wafers by photocurrent measurements, J. Appl. Phys., 1994, 75(8),4000-4008.[6]Liang Weiguo, Han Jinghong, Zhang Hong and Chen Deyong, A Light Addressable Potentiometric with an Array of Sensing Regions, Proc.[J]. SPIE.2001,4414:386- -
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