Abstract: A multimedia streams self-regulating algorithm based on fuzzy immune PID is proposed to attain the goal of on-line self-regulating of multimedia streams and effective resource management. Model of adaptive session is analyzed, and available bandwidth future estimation is achieved. The fuzzy nonlinear approximation of immune suppresser is fulfilled by fuzzy rules self-tuning with self-tuning factor in full domain. Then, in order to improve the traditional PID algorithm fuzzy nonlinear approximation is combined with immune feedback mechanism to adjust PID factors during the course of multimedia transmission. Simulation validates the theoretical results of MFIPID.