Abstract: Wireless Sensor Networks (WSNs) have such characteristics as energy depletion and nodes random failure fault caused by harsh environment. So in this paper, a Fault-tolerant Topology Control Approach (FTCA), which can optimize node energy and random failure simultaneously is proposed. This method can built the fault model based on the node energy depletion and random failure, find the node degree parameter which can satisfy the double requirements of the network lifetime and the tolerance to integrated fault, obtain the target topology to maximize the lifetime, and improve the fault tolerance to the energy depletion and random failure of nodes. Finally, the experimental results show the effectiveness of the FTCA algorithm.